diff --git a/.ci.yaml b/.ci.yaml
index c49dcbebce..ff7e45df2f 100644
--- a/.ci.yaml
+++ b/.ci.yaml
@@ -3345,6 +3345,8 @@ targets:
   - name: Mac build_ios_framework_module_test
     recipe: devicelab/devicelab_drone
     timeout: 60
+    # Flake rate of >3.5% in presubmit
+    presubmit: false # https://github.com/flutter/flutter/issues/150642
     properties:
       add_recipes_cq: "true"
       dependencies: >-
@@ -3457,6 +3459,8 @@ targets:
   - name: Mac_arm64 build_tests_1_4
     recipe: flutter/flutter_drone
     timeout: 60
+    # Flake rate of >2.5% in presubmit
+    presubmit: false # https://github.com/flutter/flutter/issues/150642
     properties:
       add_recipes_cq: "true"
       dependencies: >-
@@ -3863,6 +3867,8 @@ targets:
   - name: Mac_arm64 module_test_ios
     recipe: devicelab/devicelab_drone
     timeout: 60
+    # Flake rate of >10% in presubmit
+    presubmit: false # https://github.com/flutter/flutter/issues/150642
     properties:
       dependencies: >-
         [
@@ -4044,6 +4050,8 @@ targets:
   - name: Mac tool_integration_tests_1_4
     recipe: flutter/flutter_drone
     timeout: 60
+    # Flake rate of >2.5% in presubmit
+    presubmit: false # https://github.com/flutter/flutter/issues/150642
     properties:
       add_recipes_cq: "true"
       dependencies: >-