diff --git a/packages/flutter/lib/src/material/menu_anchor.dart b/packages/flutter/lib/src/material/menu_anchor.dart
index b87d0d4d45..503286e371 100644
--- a/packages/flutter/lib/src/material/menu_anchor.dart
+++ b/packages/flutter/lib/src/material/menu_anchor.dart
@@ -848,6 +848,7 @@ class MenuItemButton extends StatefulWidget {
     this.onFocusChange,
     this.focusNode,
     this.shortcut,
+    this.semanticsLabel,
     this.style,
     this.statesController,
     this.clipBehavior = Clip.none,
@@ -892,6 +893,21 @@ class MenuItemButton extends StatefulWidget {
   /// {@macro flutter.material.MenuBar.shortcuts_note}
   final MenuSerializableShortcut? shortcut;
 
+  /// An optional Semantics label, applied to the entire [MenuItemButton].
+  ///
+  /// A screen reader will default to reading the derived text on the
+  /// [MenuItemButton] itself, which is not guaranteed to be readable.
+  /// (For some shortcuts, such as comma, semicolon, and other
+  /// punctuation, screen readers read silence)
+  ///
+  /// Setting this label overwrites the semantics properties of the entire
+  /// Widget, including its children. Consider wrapping this widget in
+  /// [Semantics] if you want to customize other properties besides just
+  /// the label.
+  ///
+  /// Null by default.
+  final String? semanticsLabel;
+
   /// Customizes this button's appearance.
   ///
   /// Non-null properties of this style override the corresponding properties in
@@ -1119,6 +1135,7 @@ class _MenuItemButtonState extends State<MenuItemButton> {
       child: _MenuItemLabel(
         leadingIcon: widget.leadingIcon,
         shortcut: widget.shortcut,
+        semanticsLabel: widget.semanticsLabel,
         trailingIcon: widget.trailingIcon,
         hasSubmenu: false,
         overflowAxis: _anchor?._orientation ?? widget.overflowAxis,
@@ -2973,6 +2990,7 @@ class _MenuItemLabel extends StatelessWidget {
     this.leadingIcon,
     this.trailingIcon,
     this.shortcut,
+    this.semanticsLabel,
     this.overflowAxis = Axis.vertical,
     required this.child,
   });
@@ -2997,6 +3015,10 @@ class _MenuItemLabel extends StatelessWidget {
   /// the shortcut.
   final MenuSerializableShortcut? shortcut;
 
+  /// An optional Semantics label, which replaces the generated string when
+  /// read by a screen reader.
+  final String? semanticsLabel;
+
   /// The direction in which the menu item expands.
   final Axis overflowAxis;
 
@@ -3010,7 +3032,6 @@ class _MenuItemLabel extends StatelessWidget {
       _kLabelItemMinSpacing,
       _kLabelItemDefaultSpacing + density.horizontal * 2,
     );
-
     Widget leadings;
     if (overflowAxis == Axis.vertical) {
       leadings = Expanded(
@@ -3044,7 +3065,7 @@ class _MenuItemLabel extends StatelessWidget {
       );
     }
 
-    return Row(
+    Widget menuItemLabel = Row(
       mainAxisAlignment: MainAxisAlignment.spaceBetween,
       children: <Widget>[
         leadings,
@@ -3073,6 +3094,10 @@ class _MenuItemLabel extends StatelessWidget {
           ),
       ],
     );
+    if (semanticsLabel != null) {
+      menuItemLabel = Semantics(label: semanticsLabel, excludeSemantics: true, child: menuItemLabel);
+    }
+    return menuItemLabel;
   }
 
   @override
diff --git a/packages/flutter/test/material/menu_anchor_test.dart b/packages/flutter/test/material/menu_anchor_test.dart
index 9cd9de3985..3490734468 100644
--- a/packages/flutter/test/material/menu_anchor_test.dart
+++ b/packages/flutter/test/material/menu_anchor_test.dart
@@ -3387,6 +3387,27 @@ void main() {
       semantics.dispose();
     });
 
+   testWidgets('MenuItemButton semantics respects label', (WidgetTester tester) async {
+      final SemanticsTester semantics = SemanticsTester(tester);
+      await tester.pumpWidget(
+        MaterialApp(
+          home: Center(
+            child: MenuItemButton(
+              semanticsLabel: 'TestWidget',
+              shortcut: const SingleActivator(LogicalKeyboardKey.comma),
+              style: MenuItemButton.styleFrom(fixedSize: const Size(88.0, 36.0)),
+              onPressed: () {},
+              child: const Text('ABC'),
+            ),
+          ),
+        ),
+      );
+
+      expect(find.bySemanticsLabel('TestWidget'), findsOneWidget);
+      semantics.dispose();
+    }, variant: TargetPlatformVariant.desktop());
+
+
     testWidgets('SubMenuButton is not a semantic button', (WidgetTester tester) async {
       final SemanticsTester semantics = SemanticsTester(tester);
       await tester.pumpWidget(