diff --git a/packages/flutter/lib/src/widgets/scroll_configuration.dart b/packages/flutter/lib/src/widgets/scroll_configuration.dart
index 0b0a6dc0d8..8455e6ef7f 100644
--- a/packages/flutter/lib/src/widgets/scroll_configuration.dart
+++ b/packages/flutter/lib/src/widgets/scroll_configuration.dart
@@ -5,6 +5,7 @@
 import 'package:flutter/foundation.dart';
 import 'package:flutter/gestures.dart';
 import 'package:flutter/rendering.dart';
+import 'package:flutter/services.dart' show LogicalKeyboardKey;
 
 import 'framework.dart';
 import 'overscroll_indicator.dart';
@@ -100,6 +101,7 @@ class ScrollBehavior {
     bool? scrollbars,
     bool? overscroll,
     Set<PointerDeviceKind>? dragDevices,
+    Set<LogicalKeyboardKey>? pointerAxisModifiers,
     ScrollPhysics? physics,
     TargetPlatform? platform,
     @Deprecated(
@@ -112,9 +114,10 @@ class ScrollBehavior {
       delegate: this,
       scrollbars: scrollbars ?? true,
       overscroll: overscroll ?? true,
+      dragDevices: dragDevices,
+      pointerAxisModifiers: pointerAxisModifiers,
       physics: physics,
       platform: platform,
-      dragDevices: dragDevices,
       androidOverscrollIndicator: androidOverscrollIndicator
     );
   }
@@ -132,6 +135,25 @@ class ScrollBehavior {
   /// impossible to select text in scrollable containers and is not recommended.
   Set<PointerDeviceKind> get dragDevices => _kTouchLikeDeviceTypes;
 
+  /// A set of [LogicalKeyboardKey]s that, when any or all are pressed in
+  /// combination with a [PointerDeviceKind.mouse] pointer scroll event, will
+  /// flip the axes of the scroll input.
+  ///
+  /// This will for example, result in the input of a vertical mouse wheel, to
+  /// move the [ScrollPosition] of a [ScrollView] with an [Axis.horizontal]
+  /// scroll direction.
+  ///
+  /// If other keys exclusive of this set are pressed during a scroll event, in
+  /// conjunction with keys from this set, the scroll input will still be
+  /// flipped.
+  ///
+  /// Defaults to [LogicalKeyboardKey.shiftLeft],
+  /// [LogicalKeyboardKey.shiftRight].
+  Set<LogicalKeyboardKey> get pointerAxisModifiers => <LogicalKeyboardKey>{
+    LogicalKeyboardKey.shiftLeft,
+    LogicalKeyboardKey.shiftRight,
+  };
+
   /// Applies a [RawScrollbar] to the child widget on desktop platforms.
   Widget buildScrollbar(BuildContext context, Widget child, ScrollableDetails details) {
     // When modifying this function, consider modifying the implementation in
@@ -261,12 +283,14 @@ class _WrappedScrollBehavior implements ScrollBehavior {
     required this.delegate,
     this.scrollbars = true,
     this.overscroll = true,
+    Set<PointerDeviceKind>? dragDevices,
+    Set<LogicalKeyboardKey>? pointerAxisModifiers,
     this.physics,
     this.platform,
-    Set<PointerDeviceKind>? dragDevices,
     AndroidOverscrollIndicator? androidOverscrollIndicator,
   }) : _androidOverscrollIndicator = androidOverscrollIndicator,
-       _dragDevices = dragDevices;
+       _dragDevices = dragDevices,
+       _pointerAxisModifiers = pointerAxisModifiers;
 
   final ScrollBehavior delegate;
   final bool scrollbars;
@@ -274,12 +298,16 @@ class _WrappedScrollBehavior implements ScrollBehavior {
   final ScrollPhysics? physics;
   final TargetPlatform? platform;
   final Set<PointerDeviceKind>? _dragDevices;
+  final Set<LogicalKeyboardKey>? _pointerAxisModifiers;
   @override
   final AndroidOverscrollIndicator? _androidOverscrollIndicator;
 
   @override
   Set<PointerDeviceKind> get dragDevices => _dragDevices ?? delegate.dragDevices;
 
+  @override
+  Set<LogicalKeyboardKey> get pointerAxisModifiers => _pointerAxisModifiers ?? delegate.pointerAxisModifiers;
+
   @override
   AndroidOverscrollIndicator get androidOverscrollIndicator => _androidOverscrollIndicator ?? delegate.androidOverscrollIndicator;
 
@@ -303,17 +331,19 @@ class _WrappedScrollBehavior implements ScrollBehavior {
   ScrollBehavior copyWith({
     bool? scrollbars,
     bool? overscroll,
+    Set<PointerDeviceKind>? dragDevices,
+    Set<LogicalKeyboardKey>? pointerAxisModifiers,
     ScrollPhysics? physics,
     TargetPlatform? platform,
-    Set<PointerDeviceKind>? dragDevices,
     AndroidOverscrollIndicator? androidOverscrollIndicator
   }) {
     return delegate.copyWith(
       scrollbars: scrollbars ?? this.scrollbars,
       overscroll: overscroll ?? this.overscroll,
+      dragDevices: dragDevices ?? this.dragDevices,
+      pointerAxisModifiers: pointerAxisModifiers ?? this.pointerAxisModifiers,
       physics: physics ?? this.physics,
       platform: platform ?? this.platform,
-      dragDevices: dragDevices ?? this.dragDevices,
       androidOverscrollIndicator: androidOverscrollIndicator ?? this.androidOverscrollIndicator,
     );
   }
@@ -333,9 +363,10 @@ class _WrappedScrollBehavior implements ScrollBehavior {
     return oldDelegate.delegate.runtimeType != delegate.runtimeType
         || oldDelegate.scrollbars != scrollbars
         || oldDelegate.overscroll != overscroll
+        || !setEquals<PointerDeviceKind>(oldDelegate.dragDevices, dragDevices)
+        || !setEquals<LogicalKeyboardKey>(oldDelegate.pointerAxisModifiers, pointerAxisModifiers)
         || oldDelegate.physics != physics
         || oldDelegate.platform != platform
-        || !setEquals<PointerDeviceKind>(oldDelegate.dragDevices, dragDevices)
         || delegate.shouldNotify(oldDelegate.delegate);
   }
 
diff --git a/packages/flutter/lib/src/widgets/scrollable.dart b/packages/flutter/lib/src/widgets/scrollable.dart
index 0ef83c64cc..73e50961c3 100644
--- a/packages/flutter/lib/src/widgets/scrollable.dart
+++ b/packages/flutter/lib/src/widgets/scrollable.dart
@@ -756,12 +756,32 @@ class ScrollableState extends State<Scrollable> with TickerProviderStateMixin, R
     );
   }
 
-  // Returns the delta that should result from applying [event] with axis and
-  // direction taken into account.
+  // Returns the delta that should result from applying [event] with axis,
+  // direction, and any modifiers specified by the ScrollBehavior taken into
+  // account.
   double _pointerSignalEventDelta(PointerScrollEvent event) {
-    double delta = widget.axis == Axis.horizontal
-      ? event.scrollDelta.dx
-      : event.scrollDelta.dy;
+    late double delta;
+    final Set<LogicalKeyboardKey> pressed = HardwareKeyboard.instance.logicalKeysPressed;
+    final bool flipAxes = pressed.any(_configuration.pointerAxisModifiers.contains) &&
+      // Axes are only flipped for physical mouse wheel input.
+      // On some platforms, like web, trackpad input is handled through pointer
+      // signals, but should not be included in this axis modifying behavior.
+      // This is because on a trackpad, all directional axes are available to
+      // the user, while mouse scroll wheels typically are restricted to one
+      // axis.
+      event.kind == PointerDeviceKind.mouse;
+
+    switch (widget.axis) {
+      case Axis.horizontal:
+        delta = flipAxes
+          ? event.scrollDelta.dy
+          : event.scrollDelta.dx;
+        break;
+      case Axis.vertical:
+        delta = flipAxes
+          ? event.scrollDelta.dx
+          : event.scrollDelta.dy;
+    }
 
     if (axisDirectionIsReversed(widget.axisDirection)) {
       delta *= -1;
diff --git a/packages/flutter/test/widgets/scrollable_test.dart b/packages/flutter/test/widgets/scrollable_test.dart
index 4b5e379290..2c7d236ce0 100644
--- a/packages/flutter/test/widgets/scrollable_test.dart
+++ b/packages/flutter/test/widgets/scrollable_test.dart
@@ -16,13 +16,17 @@ Future<void> pumpTest(
   TargetPlatform? platform, {
   bool scrollable = true,
   bool reverse = false,
+  Set<LogicalKeyboardKey>? axisModifier,
+  Axis scrollDirection = Axis.vertical,
   ScrollController? controller,
   bool enableMouseDrag = true,
 }) async {
   await tester.pumpWidget(MaterialApp(
-    scrollBehavior: const NoScrollbarBehavior().copyWith(dragDevices: enableMouseDrag
-      ? <ui.PointerDeviceKind>{...ui.PointerDeviceKind.values}
-      : null,
+    scrollBehavior: const NoScrollbarBehavior().copyWith(
+      dragDevices: enableMouseDrag
+        ? <ui.PointerDeviceKind>{...ui.PointerDeviceKind.values}
+        : null,
+      pointerAxisModifiers: axisModifier,
     ),
     theme: ThemeData(
       platform: platform,
@@ -30,9 +34,13 @@ Future<void> pumpTest(
     home: CustomScrollView(
       controller: controller,
       reverse: reverse,
+      scrollDirection: scrollDirection,
       physics: scrollable ? null : const NeverScrollableScrollPhysics(),
-      slivers: const <Widget>[
-        SliverToBoxAdapter(child: SizedBox(height: 2000.0)),
+      slivers: <Widget>[
+        SliverToBoxAdapter(child: SizedBox(
+          height: scrollDirection == Axis.vertical ? 2000.0 : null,
+          width: scrollDirection == Axis.horizontal ? 2000.0 : null,
+        )),
       ],
     ),
   ));
@@ -399,6 +407,118 @@ void main() {
     expect(getScrollOffset(tester), 20.0);
   });
 
+  testWidgets('Scrolls horizontally when shift is pressed by default', (WidgetTester tester) async {
+    await pumpTest(
+      tester,
+      debugDefaultTargetPlatformOverride,
+      scrollDirection: Axis.horizontal,
+    );
+
+    final Offset scrollEventLocation = tester.getCenter(find.byType(Viewport));
+    final TestPointer testPointer = TestPointer(1, ui.PointerDeviceKind.mouse);
+    // Create a hover event so that |testPointer| has a location when generating the scroll.
+    testPointer.hover(scrollEventLocation);
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input not accepted
+    expect(getScrollOffset(tester), 0.0);
+
+    await tester.sendKeyDownEvent(LogicalKeyboardKey.shift);
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input flipped to horizontal and accepted.
+    expect(getScrollOffset(tester), 20.0);
+    await tester.sendKeyUpEvent(LogicalKeyboardKey.shift);
+    await tester.pump();
+
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input not accepted
+    expect(getScrollOffset(tester), 20.0);
+  }, variant: TargetPlatformVariant.all());
+
+  testWidgets('Scroll axis is not flipped for trackpad', (WidgetTester tester) async {
+    await pumpTest(
+      tester,
+      debugDefaultTargetPlatformOverride,
+      scrollDirection: Axis.horizontal,
+    );
+
+    final Offset scrollEventLocation = tester.getCenter(find.byType(Viewport));
+    final TestPointer testPointer = TestPointer(1, ui.PointerDeviceKind.trackpad);
+    // Create a hover event so that |testPointer| has a location when generating the scroll.
+    testPointer.hover(scrollEventLocation);
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input not accepted
+    expect(getScrollOffset(tester), 0.0);
+
+    await tester.sendKeyDownEvent(LogicalKeyboardKey.shift);
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input not flipped.
+    expect(getScrollOffset(tester), 0.0);
+    await tester.sendKeyUpEvent(LogicalKeyboardKey.shift);
+    await tester.pump();
+
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input not accepted
+    expect(getScrollOffset(tester), 0.0);
+  }, variant: TargetPlatformVariant.all());
+
+  testWidgets('Scrolls horizontally when custom key is pressed', (WidgetTester tester) async {
+    await pumpTest(
+      tester,
+      debugDefaultTargetPlatformOverride,
+      scrollDirection: Axis.horizontal,
+      axisModifier: <LogicalKeyboardKey>{ LogicalKeyboardKey.altLeft },
+    );
+
+    final Offset scrollEventLocation = tester.getCenter(find.byType(Viewport));
+    final TestPointer testPointer = TestPointer(1, ui.PointerDeviceKind.mouse);
+    // Create a hover event so that |testPointer| has a location when generating the scroll.
+    testPointer.hover(scrollEventLocation);
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input not accepted
+    expect(getScrollOffset(tester), 0.0);
+
+    await tester.sendKeyDownEvent(LogicalKeyboardKey.altLeft);
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input flipped to horizontal and accepted.
+    expect(getScrollOffset(tester), 20.0);
+    await tester.sendKeyUpEvent(LogicalKeyboardKey.altLeft);
+    await tester.pump();
+
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input not accepted
+    expect(getScrollOffset(tester), 20.0);
+  }, variant: TargetPlatformVariant.all());
+
+  testWidgets('Still scrolls horizontally when other keys are pressed at the same time', (WidgetTester tester) async {
+    await pumpTest(
+      tester,
+      debugDefaultTargetPlatformOverride,
+      scrollDirection: Axis.horizontal,
+      axisModifier: <LogicalKeyboardKey>{ LogicalKeyboardKey.altLeft },
+    );
+
+    final Offset scrollEventLocation = tester.getCenter(find.byType(Viewport));
+    final TestPointer testPointer = TestPointer(1, ui.PointerDeviceKind.mouse);
+    // Create a hover event so that |testPointer| has a location when generating the scroll.
+    testPointer.hover(scrollEventLocation);
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input not accepted
+    expect(getScrollOffset(tester), 0.0);
+
+    await tester.sendKeyDownEvent(LogicalKeyboardKey.altLeft);
+    await tester.sendKeyDownEvent(LogicalKeyboardKey.space);
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical flipped & accepted.
+    expect(getScrollOffset(tester), 20.0);
+    await tester.sendKeyUpEvent(LogicalKeyboardKey.altLeft);
+    await tester.sendKeyUpEvent(LogicalKeyboardKey.space);
+    await tester.pump();
+
+    await tester.sendEventToBinding(testPointer.scroll(const Offset(0.0, 20.0)));
+    // Vertical input not accepted
+    expect(getScrollOffset(tester), 20.0);
+  }, variant: TargetPlatformVariant.all());
+
   group('setCanDrag to false with active drag gesture: ', () {
     Future<void> pumpTestWidget(WidgetTester tester, { required bool canDrag }) {
       return tester.pumpWidget(